SIRT6 links histone H3 lysine 9 deacetylation to control of NF-κB dependent gene expression and organismal lifespan
نویسندگان
چکیده
Tiara L.A. Kawahara1,2,5, Eriko Michishita3,4,5, Adam S. Adler1,2,5, Mara Damian3,4,5, Elisabeth Berber3,4,5, Meihong Lin1, Ron A. McCord2,3,4, Kristine C.L. Ongaigui1, Lisa D. Boxer3,4, Howard Y. Chang1,2,6, and Katrin F. Chua2,3,4,6 1Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA 2Cancer Biology Program, Stanford University School of Medicine, Stanford, CA 94305, USA 3Department of Medicine, Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, Stanford, CA 94305, USA
منابع مشابه
SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in multiple organisms. Deficiency of mammalian SIRT6 leads to shortened life span and an aging-like phenotype in mice, but the underlying molecular mechanisms are unclear. Here we show that SIRT6 functions at chromatin to attenuate NF-kappaB signaling. SIRT6 interacts with the NF-kappaB RELA subunit and deacety...
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